So, I did a little soul-searching (okay, very little) to defend my position. Why do I believe, fundamentally, that liquid (or hybrid) layouts are great idea? Accessibility is the first thing that comes to mind. A liquid display doesn't care what your monitor resolution is. It doesn't require someone with a small screen to scroll to the right to see stuff. It gives a similar user experience to everyone.
Mobile devices is the second thing that comes to mind. How can anyone possibly keep up with all the mobile web devices out there, and design specifically for each resolution?
So, why wouldn't you use liquid displays? Well, it's easier to design, build and test. Just like the argument for only supporting One Browser. And you can maintain the integrity of your visual design without worrying about things "flying around".
Needing more ammunition, I resorted to the most popular research tool: Google. I turned up http://cssliquid.com, dedicated to the promotion of liquid/hybrid displays, which had some great examples (see for yourself). The examples there aren't all great, but some are quite effective. Like any other usability guideline: "Where it makes sense."
There are many
All you designers: be open to liquid displays. It doesn't challenge the integrity of your design; it challenges the integrity of your design ability.